0000001 - Document - Cover link:presentationLink link:calculationLink link:definitionLink 9952151 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS link:presentationLink link:calculationLink link:definitionLink 9952152 - Statement - CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) link:presentationLink link:calculationLink link:definitionLink 9952153 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS link:presentationLink link:calculationLink link:definitionLink 9952154 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS link:presentationLink link:calculationLink link:definitionLink 9952155 - Statement - CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY link:presentationLink link:calculationLink link:definitionLink 9952156 - Statement - CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS link:presentationLink link:calculationLink link:definitionLink 9952157 - Disclosure - Nature of the business link:presentationLink link:calculationLink link:definitionLink 9952158 - Disclosure - Summary of significant accounting policies link:presentationLink link:calculationLink link:definitionLink 9952159 - Disclosure - Fair value of financial assets and liabilities link:presentationLink link:calculationLink link:definitionLink 9952160 - Disclosure - Short-term investments link:presentationLink link:calculationLink link:definitionLink 9952161 - Disclosure - Property, plant and equipment, net link:presentationLink link:calculationLink link:definitionLink 9952162 - Disclosure - Accrued expenses and other current liabilities link:presentationLink link:calculationLink link:definitionLink 9952163 - Disclosure - Debt link:presentationLink link:calculationLink link:definitionLink 9952164 - Disclosure - Stockholders' equity link:presentationLink link:calculationLink link:definitionLink 9952165 - Disclosure - Pre-funded Warrants link:presentationLink link:calculationLink link:definitionLink 9952166 - Disclosure - Stock-based compensation link:presentationLink link:calculationLink link:definitionLink 9952167 - Disclosure - Net loss per share link:presentationLink link:calculationLink link:definitionLink 9952168 - Disclosure - Significant agreements link:presentationLink link:calculationLink link:definitionLink 9952169 - Disclosure - Collaboration and other arrangements link:presentationLink link:calculationLink link:definitionLink 9952170 - Disclosure - Commitments and contingencies link:presentationLink link:calculationLink link:definitionLink 9952171 - Disclosure - Income taxes link:presentationLink link:calculationLink link:definitionLink 9952172 - Disclosure - Geographic information link:presentationLink link:calculationLink link:definitionLink 9952173 - Disclosure - Segment information link:presentationLink link:calculationLink link:definitionLink 9952174 - Disclosure - Subsequent Events link:presentationLink link:calculationLink link:definitionLink 9955511 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:calculationLink link:definitionLink 9955512 - Disclosure - Fair value of financial assets and liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955513 - Disclosure - Short-term investments (Tables) link:presentationLink link:calculationLink link:definitionLink 9955514 - Disclosure - Property, plant and equipment, net (Tables) link:presentationLink link:calculationLink link:definitionLink 9955515 - Disclosure - Accrued expenses and other current liabilities (Tables) link:presentationLink link:calculationLink link:definitionLink 9955516 - Disclosure - Debt (Tables) link:presentationLink link:calculationLink link:definitionLink 9955517 - Disclosure - Stockholders' equity (Tables) link:presentationLink link:calculationLink link:definitionLink 9955518 - Disclosure - Stock-based compensation (Tables) link:presentationLink link:calculationLink link:definitionLink 9955519 - Disclosure - Net loss per share (Tables) link:presentationLink link:calculationLink link:definitionLink 9955520 - Disclosure - Commitments and contingencies (Tables) link:presentationLink link:calculationLink link:definitionLink 9955521 - 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Disclosure - Debt - Schedule of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955530 - Disclosure - Debt - Schedule of Maturity of Debt (Details) link:presentationLink link:calculationLink link:definitionLink 9955531 - Disclosure - Stockholders' equity - Common Stock and Undesignated Preferred Stock (Details) link:presentationLink link:calculationLink link:definitionLink 9955532 - Disclosure - Stockholders' equity - Schedule of Pre-funded Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 9955533 - Disclosure - Stockholders' equity - ATM Program (Details) link:presentationLink link:calculationLink link:definitionLink 9955534 - Disclosure - Stockholders' equity - Equity offerings (Details) link:presentationLink link:calculationLink link:definitionLink 9955535 - Disclosure - Pre-funded Warrants (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Stock-based compensation - Classification of expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955536 - Disclosure - Stock-based compensation - Classification of expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955537 - Disclosure - Stock-based compensation - Additional Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955538 - Disclosure - Stock-based compensation - Assumptions to determine grant-date fair value of stock options (Details) link:presentationLink link:calculationLink link:definitionLink 9955539 - Disclosure - Stock-based compensation - Stock option activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955540 - Disclosure - Stock-based compensation - Summary of RSU Activity (Details) link:presentationLink link:calculationLink link:definitionLink 9955541 - Disclosure - Net loss per share - Computation of Net Loss per Share (Details) link:presentationLink link:calculationLink link:definitionLink 9955542 - Disclosure - Net loss per share - Narrative (Details) link:presentationLink link:calculationLink link:definitionLink 9955543 - Disclosure - Net loss per share - Computation of diluted net loss per share attributable to common stockholders (Details) link:presentationLink link:calculationLink link:definitionLink 9955544 - Disclosure - Significant agreements (Details) link:presentationLink link:calculationLink link:definitionLink 9955545 - Disclosure - Collaboration and other arrangements (Details) link:presentationLink link:calculationLink link:definitionLink 9955546 - Disclosure - Commitments and contingencies - Components of lease expense (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Commitments and contingencies - Income Statement Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955547 - Disclosure - Commitments and contingencies - Income Statement Information (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Commitments and contingencies - Balance sheet disclosures (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Commitments and contingencies - Balance sheet disclosures (Details) link:presentationLink link:calculationLink link:definitionLink 9955548 - Disclosure - Commitments and contingencies - Balance sheet disclosures (Details) link:presentationLink link:calculationLink link:definitionLink 9955549 - Disclosure - Commitments and contingencies - Other information (Details) link:presentationLink link:calculationLink link:definitionLink 9955550 - Disclosure - Commitments and contingencies - Additional information (Details) link:presentationLink link:calculationLink link:definitionLink 9955551 - Disclosure - Geographic information (Details) link:presentationLink link:calculationLink link:definitionLink 9955552 - Disclosure - Segment information (Details) link:presentationLink link:calculationLink link:definitionLink 9955553 - Disclosure - Subsequent Events (Details) link:presentationLink link:calculationLink link:definitionLink